Frequency Analysis Results Distribution of C589t Rs2243250 Polymorphism in Il4 Gene Among Patients with Chronic Rhinosinusitis

The fairly widespread prevalence of CRSwNP along with the lack remedies for curing disease, a variety hypotheses etiology dictate need further study all links in pathogenesis and clinical features course disease. In coming century “biological medicine”, availability high technologies medical genetics makes it possible to reveal individual characteristics most important regulatory systems body, which opens up new prospects studying CRSwNP. tissues polyps intranasal secretions, an increase concentration various inflammatory mediators, particular interleukins, is observed due their de novo synthesis by effector cells. Particular importance attached cytokines involved development, recruitment activation eosinophils (IL-4, IL-12, IL-13, GM-CSF), main pro-inflammatory (IL-1, IL-2, TNF-a, IL- 10), (IL-10, TLR2B), contributing chronicity process nasal cavity.